Jpn J Cancer
Res. 1998 Feb;89(2):105-9.
Induction of squamous cell carcinomas
in the salivary glands of rats by
Division of Pathology, National Institute of Health
In a 2-year carcinogenicity study of potassium iodide (KI)
in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the
salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water.
Ductular proliferation with lobular atrophy was observed at
high incidence in the submandibular glands of the high-dose animals, and
squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts.
A transition from metaplasia to SCC was apparent.
The results suggest that squamous metaplasia in proliferative
ductules, occurring secondarily to lobular impairment induced by KI, may
develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.
PMID: 9548435 [PubMed - indexed for