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1: Jpn J Cancer Res. 1998 Feb;89(2):105-9. Links

Induction of squamous cell carcinomas
in the salivary glands of rats by potassium iodide.

Division of Pathology, National Institute of Health Sciences, Tokyo.

In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water.

Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts.

A transition from metaplasia to SCC was apparent.

The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.

PMID: 9548435 [PubMed - indexed for MEDLINE]