Alprazolam (Xanax)


  • Anxiolytic


  • Benzodiazepine


  • Anxiety, panic disorder, anxiety with depressive symptoms

  • Depression, agoraphobia with social phobia (2-8mg daily): Not FDA approved


  • Untreated narrow-angle glaucoma, psychosis

  • Concurrent treatment with ketoconazole, itraconazole, nefazadone


  • Pregnancy category D

  • Elderly, debilitated, hepatic disease, renal disease, suicidal patients

Adverse Reactions (Side Effects):

  • CNS: anxiety, ataxia, confusion, dizziness, drowsiness, fatigue, hallucinations, headache, insomnia, stimulation, tremors

  • CV: bradycardia, hypertension, orthostatic hypotension, tachycardia

  • EENT: blurred vision, mydriasis, tinnitus

  • GI: anorexia, constipation, diarrhea, dry mouth, hepatic dysfunction, nausea, vomiting

  • SKIN: dermatitis, itching, rash



Administered orally

  • Adult:            

    • Anxiety: PO 0.25-0.5mg 3 times daily, up to 4mg daily in divided doses

    • Panic disorder: PO 0.5mg 3 times daily; increase dose every 3-4 days in 1mg per day increments to 10mg daily

  • Geriatric: PO 0.25mg 2-3 times daily


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