Ceftazidime (Fortaz, Ceptaz, Tazicef, Tazidime)

Category:

  • Antibiotic

Description:

  • Cephalosporin, Third Generation

Indications:

  • Lower respiratory tract infections (P. aeruginosa  and other Pseudomanas species, H. influenzae, Klebsiella species, S. pneumoniae, S. aureus, E. coli, Serratia species, Enterobacter species, P. mirabilis, Citrobacter species)

  • Urinary tract infections (E. coli, Klebsiella species, Proteus species, Enterobacter species, P. aeruginosa)

  • Skin, bone and joint infections (P. aeruginosa, Enterobacter species, E. coli, Proteus species, Klebsiella species, Serratia species, E. coli, S. aureus, S. pyogenes)

  • Intra-abdominal infections (E. coli, Klebsiella species, S. aureus, Bacteroides species, polymicrobial infections caused by aerobic and anaerobic organisms)

  • Bacterial septicemia (P. aeruginosa, Klebsiella species, H. influenzae, E. coli, Serratia species, S. pneumoniae, S. aureus)

  • Gynecological infections (E. coli)

  • CNS infections (H. influenzae, N. meningitidis)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis

Dosage:

  • Administered by injection (IM and IV)

  • Adults:

    • 1 gram IV or IM every 8-12 hours

  • uncomplicated urinary tract infections: 

    • 250mg IV or IM every 12 hours

  • complicated urinary tract infections: 

    • 500mg IV or IM every 8-12 hours

  • meningitis: 

    • 2 grams IV every 8 hours

  • uncomplicated pneumonia, mild skin infections: 

    • 500mg 1 gram IV or IM every 8 hours

  • bone and joint infections: 

    • 2 grams IV every 12 hours

  • meningitis: 

    • 2 grams IV every 8 hours

  • severe, life-threatening infections: 

    • 2 grams IV every 8 hours

  • pseudomonal lung infections: 

    • 30-50mg/kg IV every 8 hours (maximum 6 grams per day)

  • Infants and Children (1 month 1 year)

    • 30-50mg/kg IV every 8 hours (maximum 6 grams per day)

  • Neonates (0-4 weeks):

    • 30mg/kg IV every 12 hours

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