Cephradine (Velosef)

Category:

  • Antibiotic

Description:

  • Cephalosporin, First Generation

Indications:

  • Respiratory tract infections (S. pneumoniae, group A beta-hemolytic streptococci)

  • Otitis media (S. pneumoniae, H. influenzae, staphylococci, group A beta-hemolytic streptococci)

  • Urinary tract infections (E. coli, Klebsiella species, P. mirabilis)

  • Skin, bone, and joint infections (staphylococci, A beta-hemolytic streptococci)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Counsel patient to finish all medication to prevent development of resistance

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  

Dosage:

  • Administered orally (capsules and oral suspension) and by IM or IV injection

  • Adults:

    • Skin, Resp Tract infections: 250mg every 6 hours or 500mg every 12 hours

    • Lobar pneumonia: 500mg every 6 hours or 1 gram every 12 hours

    • Uncomplicated UTI: 500mg every 12 hours

    • Serious infections and prostatitis: 500mg every 6 hours or 1 gram every 12 hours

  • Children > 9 months old:

    • 25-50mg/kg/day in divided doses every 6 or 12 hours

    • Otitis media form H. influenzae: 75-100mg/kg/day every 6 or 12 hours (not to exceed 4 grams a day)

  • Parenteral:

    • Adults: 2-4 grams in equally divided does 4 times a day

    • Bone infections: 1 gram IV four times a day

    • Cesarean section: 1 gram IV immediately after umbilical cord is clamped, give 2d and 3rd doses as 1 gram IM or IV at 6-12 hours after first dose

  • Perioperative prophylaxis:

    • Pre-op: 1 gram IV or IM, 30 to 90 minutes pre-surgery

    • Intra- and Post-operative (>2 hours): 1 gram IV or IM every 4 to 6 hours for 1 or 2 dose

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