Chloroquine and Primaquine (Aralen with Primaquine)

Category:

  • Antimalarial

Description:

  • Chloroquine and primaquine are used together in an oral preparation to prevent malaria.  Chloroquine and primaquine are both antimalarial agents; primaquine is added to cover for chloroquine-resistant strains of P. falciparum

Indications:

  • malaria prophylaxis

Contraindications:

  • Retinal field changes, porphyria

Precautions:

  • Pregnancy category C

  • Children, blood dyscrasias, severe GI disease, hepatic disease

  • G-6-PD deficiency, psoriasis, eczema

Adverse Reactions (Side Effects):

  • CNS: headache, fatigue, seizures, psychosis, stimulation

  • CV: asystole with syncope, heart block, ECG changes, hypotension

  • EENT: interference with visual accommodation

  • GI: anorexia, cramps, diarrhea, nausea, vomiting,

  • HEME: hemolytic anemia in G-6-PD deficient patients, leukopenia, methemoglobinemia in NADH methemoglobin reductase-deficient patients

  • SKIN: eczema, exfoliative dermatitis, skin eruptions, pruritus

 

Dosage:

Administered orally: available as tablets:  

  • chloroquine phosphate 500mg (300mg base)

  • primaquine phosphate 79mg (45mg base)

  • Marlaria prophylaxis: Adult:  PO 1 tablet taken at least 1 day prior to entering the endemic area, and then PO 1 tablet on the same day of each week throughout the stay and for 8 weeks after leaving an endemic area

    

 
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