Diphenoxylate/Atropine (Lomotil, Lonox, Lomanate, Logen)

Category:

  • Gastrointestinal

Description:

  • Antidiarrheal: DEA Schedule V

Indications:

  • Diarrhea

  • Reduction of ileostomy discharge

Contraindications:

  • Obstructive jaundice

  • Diarrhea associated with pseudomembranous enterocolitis or entertoxin-producing bacteria

Precautions:

  • Pregnancy category C; excreted in breast milk

  • Acute ulcerative colitis (may induce toxic megacolon)

  • Severe hepatorenal disease

Adverse Reactions (Side Effects):

  • Central Nervous System: fatigue, dizziness, drowsiness

  • Gastrointestinal: abdominal pain or distention, constipation, ileus, nausea, vomiting

  • Dry Mouth

  • Rash

Dosage:

Administered orally (tablets, solution)

  • Tablet: 2.5mg diphenoxylate/0.025mg atropine 

  • Solution: 2.5mg diphenoxylate/0.025mg atropine per 5ml

  • Adult: 5mg (2 tablets) four times daily, taper dose as tolerated

  • Child: 0.3-0.4mg/kg daily in 4 divided doses

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