Dobutamine (Dobutrex)

Category:

  • Nervous system

Description:

  • Sympathomimetic

Indications:

  • Short-term treatment of adults with cardiac decompensation due to depressed myocardial contractility

Contraindications:

  • Hypertrophic cardiomyopathy

  • Uncontrolled atrial fibrillation or flutter (unless a digitalis preparation is used prior to starting therapy with dobutamine)

Precautions:

  • Pregnancy category C; excreted in breast milk

  • Children, hypertension, sulfite sensitivity

Adverse Reactions (Side Effects):

  • CNS: anxiety, dizziness, headache, paresthesia

  • CV: angina, dysrhythmia, hypertension, palpitations, PVCs, tachycardia

  • GI: heartburn, nausea, vomiting,

  • METAB: hypokalemia

  • MS: leg cramps

Dosage:

Administered intravenously

  • Adult:   

    • IV INF 2.5-15 mcg/kg/min

    • maximum dose 40 mcg/kg/min

Special Consideration:

  •  Sodium bicarbonate: alkalinizing substances inactivate dobutamine

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