Gentamicin Ophthalmic (Genoptic, Garamycin)

Gentamicin and Prednisolone ophthalmic (Pred-G, Pred-G S.O.P.)


  • Antibiotic


  • Aminoglycoside antibiotic

  • Aminoglycoside and steroidal anti-inflammatory combination


  • Ocular infections due to susceptible organisms (see Gentamicin injection monograph)


  • Generally not indicated for long-term therapy due to nephrotoxocity and ototoxicity


  • Pregnancy category D

  • Use proper ophthalmic application procedures (tilt head backward, pull lower eyelid downward to make a “cup”, avoid touching tip of bottle, drop in eye, place light pressure on lacrimal sac for ~1 minute)

  • Ophthalmic suspension must be shaken prior to use

  • Notify provider immediately at the first sign of skin rash or other allergic reaction  

  • Use of steroids in the presence of viral infections such as herpes, may prolong or worsen the severity of the viral infection.

Adverse Reactions (Side Effects):

  • Transient irritation, burning or stinging

  • May cause white crystalline precipitates and lid margin crusting


  • Administered by ophthalmic drops and ointment

  • Gentamicin Ophthalmic Drops:

    • 1-2 drops into affected eye(s) every 4 hours

  • Gentamicin Ophthalmic Ointment:

    • Apply 1/2 inch ribbon of ointment into the affected conjunctival sac(s) every 4 hours.

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