Halothane (Fluothane)

Category:

  • General anesthetic

Description:

  • Halogenated, inhalation anesthetic

Indications:

  • General anesthesia

  • Status epilepticus (non-FDA approved)

Contraindications:

  • Obstetric delivery

  • Jaundice

Precautions:

  • Breast feeding not recommended

  • Use with amiodarone may produce atropine-resistant bradycardia and hypotension

  • Potentiates effects of antihypertensive agents

  • Sensitizes myocardium to effects of sympathomimetics

  • Halothane increases the QT interval

Adverse Reactions (Side Effects):

  • CNS: delirium, headache, seizures

  • CV: asystole, cardiac arrest, PVCs, QT prolongation

  • GI: hepatic failure/necrosis, nausea, vomiting

  • OB: fetal abortion, fetal stillbirth, neonatal respiratory depression

  • MISC: carboxyhemoglobinemia, fever, pneumonitis, pulmonary edema, rash, respiratory depression, rhabdomyolysis

Dosage:

Administered by inhalation

  • General anesthesia induction and maintenance: 

    • Adult: 

      • INH range from 0.5%-3%

      • During maintenance, concentration may be progressively decreased as necessary to prevent further depth of anesthesia and/or hypotension. 

      • Maintenance use 0.5%-1.5% concentration

  • Child: 

    • Dosage must be individually determined

  • Status epilepticus: 

    • Limited data: 

      • Single case report is noted where dramatic changes in peak airway pressures corresponded to administration of 0.25%-0.75% halothane

Drug interactions:

  •  Beta blockers

  •  Aminoglycosides

  •  Antihypertensive agents

  •  Cholinesterase inhibitors

  •  Neuromuscular blockers

  •  Oxytocics

  •  Phenothiazines

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