Isoflurane (Florane)

Category:

  • General anesthetic

Description:

  • Halogenated, inhalation anesthetic

Indications:

  • General anesthesia

Contraindications:

  • Malignant hyperthermia

Precautions:

  • Pregnancy

  • Used with amiodarone, can increase risk of developing atropine-resistant bradycardia and hypotension

  • Prolongs life of ketamine

  • Potentiates the effects of antihypertensive agents

  • Decreases effectiveness of oxytocics

Adverse Reactions (Side Effects):

  • CNS: delirium, headache

  • OB: fetal abortion, fetal stillbirth, teratogenesis, neonatal respiratory depression, uterine relaxation

  • GI: hepatitis, elevated hepatic enzymes, nausea, vomiting,

  • CV: PVCs

Dosage:

Solely for inhalation administration and should only be given by individuals trained in the administration of general anesthesia.  Dosage must be individualized.

Note: For general anesthesia induction, the isoflurane concentration should be increased slowly by 0.1%-0.25% and delivered via inhalation every few breaths

  • General anesthesia induction: 

    • Adult: 

      • usual dose is 1.5%-3%

    • Child: 

      • dosage must be individually determined

  • General anesthesia maintenance: 

    • Adult: 

      • 1%-3%

    • Child: 

      • dosage must be individually determined

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