Medroxyprogesterone (Provera, Cycrin, Depo-Provera)


  • Hormonal


  • Progesterone hormone


  • Abnormal uterine bleeding (due to hormonal imbalance in the absence of organic pathology)

  • Secondary amenorrhea

  • Contraception


  • Current or history of thrombophlebitis, thromboembolic disorders, and cerebral apoplexy

  • Liver impairment, known or suspected malignancy of the breast or genitalia

  • Undiagnosed genital bleeding

  • Missed abortion

  • Use as a pregnancy diagnostic test


  • Pregnancy category D (Provera and Cycrin)

  • Pregnancy category X (Depo Provera)

  • Use with caution in pregnant or nursing mothers

  • Use with caution in patients with diabetes, epilepsy, migraine, asthma, cardiac or renal dysfunction, or history of depression.

  • Injectable form of contraception has an extended duration of three months.

  • Immediately discontinue therapy and consult health care provider if pregnancy is suspected.

Adverse Reactions (Side Effects):

  • Rash, alopecia, acne, hirsutism

  • Abnormal menstrual bleeding, changes in cervical secretions

  • Edema, weight change

  • Depression, insomnia, somnolence

  • Nausea

  • Injection site irritation


Administered orally or injection

  • Abnormal uterine bleeding: 

    • 5-10mg daily for 5-10 days initiated on 16th or 21st day of cycle

  • Secondary amenorrhea: 

    • 5-10mg daily for 5-10 days

  • Contraception: 

    • 150mg IM injection (gluteal or deltoid muscle) every three months, given in first 5 days of normal menstrual cycle

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