Mephentermine (Wyamine)

Category:

  • Nervous system

Description:

  • Antihypotensive

Indications:

  • Hypotension during spinal anesthesia

Contraindications:

  • Hypotension induced by chlorpromazine

  • Concurrent use with any MAOI

Precautions:

  • Pregnancy category C

  • Cardiovascular disease, chronically ill patients

  • Hemorrhagic shock, hyperthyroidism, hypertension

Adverse Reactions (Side Effects):

  • CNS: anxiety, confusion, drowsiness, incoherence, tremors

  • CV: hypertension, palpitations, tachydardia

Dosage:

Administered intramuscularly, intravenously

  • Adult:            

    • Prevention of hypotension during spinal anesthesia: 

      • IM 30-45mg 10-20 minutes prior to anesthesia      

    • Hypotension following spinal anesthesia: 

      • IV 30-45mg, repeat doses of 30mg as needed to maintain blood pressure

      • IV INF use 0.1% solution in D5W (1mg/ml), titrate to patient response

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