Piroxicam (Feldene)


  • Analgesic


  • Nonnarcotic angalgesic, nonsteroidal antiinflammatory drug (NSAID)


  • Osteoarthritis

  • Rheumatoid arthritis


  • Pregnancy category B (avoid administration near term); excreted into breast milk, but should not present risk to infant

  • Children, bleeding disorders

  • GI disorders, cardiac disorders

  • Asthma, renal or hepatic disease

  • Elderly

Adverse Reactions (Side Effects):

  • CNS: anxiety, confusion, depression, dizziness, drowsiness, fatigue, headache, insomnia, tremors

  • CV: dysrhythmias, palpitations, peripheral edema, tachycardia

  • EENT: blurred vision, hearing loss, tinnitus

  • GI: anorexia, bleeding, cholestatic hepatitis, constipation, cramps, diarrhea, dry mouth, flatulence, jaundice, nausea, perforation, ulceration, vomiting

  • GU: nephrotoxicity

  • HEME: blood dyscrasias

  • SKIN: photosensitivity, pruritus, purpura, rash, sweating



Administered orally

  • Adult:   PO 20mg once daily or 10mg 2 times daily

Drug interactions:

  • Anticoagulants: addition of piroxicam associated with excessive hypoprothrombinemia and bleeding; ibuprofen less likely to interact

  • Methotrexate: addition of piroxicam may interfere with the renal secretion of methotrexate, yielding increased risk of methotrexate toxicity



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