Tobramycin ophthalmic (Tobrex)

Tobramycin and Dexamethasone ophthalmic (Tobradex)

Category:

  • Antibiotic

Description:

  • Aminoglycoside antibiotic

  • Aminoglycoside and steroidal anti-inflammatory combination

Indications:

  • Ocular infections due to susceptible organisms (see Tobramycin injection monograph) 

Contraindications:

  • Generally not indicated for long-term therapy due to nephrotoxocity and ototoxicity

Precautions:

  • Pregnancy category D

  • Use proper ophthalmic application procedures (tilt head backward, pull lower eyelid downward to make a “cup”, avoid touching tip of bottle, drop in eye, place light pressure on lacrimal sac for ~1 minute)

  • Ophthalmic suspension must be shaken prior to use

  • Notify provider immediately at the first sign of skin rash or other allergic reaction

  • Use of steroids in the presence of viral infections such as herpes, may prolong or worsen the severity of the viral infection.

Adverse Reactions (Side Effects):

  • Transient irritation, burning or stinging

  • May cause white crystalline precipitates and lid margin crusting

Dosage:

  • Administered by ophthalmic drops, ointment and suspension (Tobradex)

  • Instill 1-2 drops into affected eye(s) every 4 hours

 
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