Dicloxacillin (Dynapen)


  • Antibiotic


  • Penicillinase-Resistant Penicillin


  • Mild to moderate infections caused by penicillinase-producing staphylococci

  • Upper Respiratory Tract Infections

  • Localized soft tissue/skin infections

  • Lower Respiratory Tract Infections

  • Disseminated infections


  • None


  • Pregnancy category B

  • Use with caution in patients with penicillin or cephalosporin allergy (5-10% chance of cross-reactivity)

  • Counsel patient to finish all medication to prevent development of resistance

  • Inform patient to take at even intervals, preferably around the clock

  • Take on an empty stomach, 1 hour before or 2 hours after meals.  Food inhibits absorption

Adverse Reactions (Side Effects):

  • Hypersensitivity

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  


  • Administered orally (capsules and pediatric suspension)

  • Adult and children (>40kg):

    • 125-250mg q6h

  • Child (<40kg):

    • 12.5-25mg/kg in divided doses q6h

    • oral suspension:  refrigerate, shake well, good for 14 days

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