Estradiol (Estrase, Estraderm)


  • Hormonal


  • Estrogen hormone


  • Menopausal vasomotor symptoms (hot flashes, etc.)

  • Female hypogonadism

  • Female castration and primary ovarian failure

  • Atrophic conditions caused by deficient estrogen production


  • Known or suspected breast cancer

  • Known or suspected estrogen-dependent neoplasia

  • Known or suspected pregnancy

  • Undiagnosed genital bleeding

  • Current or history of thrombophlebitis, thrombosis, thromboembolic disorders (except when used in breast or prostatic cancer treatment).


  • Pregnancy category X

  • Use with caution in patients with hypertension, diabetes, epilepsy, cardiac, liver or renal dysfunction, history of depression, gall bladder disease, hepatic adenoma.

  • Use with caution in nursing mothers.

  • Use with extreme caution in women with a family history of breast cancer or who have breast nodules.

  • Perform periodic breast examinations.

  • Rotate patch application sites to decrease skin sensitivity.

  • May decrease glucose intolerance in diabetic patients.

  • Discontinue therapy and contact health care provider if pregnancy is suspected.

Adverse Reactions (Side Effects):

  • Thromboembolic disorders

  • Abnormal menstrual bleeding, breast tenderness

  • Edema, weight change

  • Depression

  • Application site irritation


  • Administered orally or transdermal patch

  • 1-2gm per day, attempting to achieve lowest possible dose

  • 10-20cm2 per patch applied twice weekly, rotating sites (avoid breasts and waistline)

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