Indomethacin (Indocin)

Category:

  • Analgesic

Description:

  • Nonsteroidal anti-inflammatory drug (NSAID) analgesic

Indications:

  • Inflammatory disease (rheumatoid and osteoarthritis)

  • Mild to moderate pain (orthopedic pain, dental procedures, dysmenorrhea)

  • Gout  

Contraindications:

  • Patients with aspirin or NSAID-induced nasal polyps, bronchospasm or angioedema  

Precautions:

  • Patients may experience potentially serious GI effects, including GI bleeding and ulceration with prolonged, high dose therapy.

  • Avoid use with anticoagulants (warfarin) due to increased bleeding times and potential for GI bleeding and decreased platelet aggregation.

  • May mask signs of infection, use with caution in the presence of infection.

  • Compliance with therapy is essential, may take up to two weeks to see noticeable improvement.

  • Always take with food, after meal or with antacids to decrease GI upset.

  • Pregnancy Category 

Adverse Reactions (Side Effects):

  • GI effects (nausea, heartburn, dyspepsia, pain)

  • CNS effects (drowsiness, dizziness, headache, nervousness)

  • Tinnitis, blurry vision, headache

Dosage:

Administered orally with food or milk to decrease GI effects

Inflammatory diseases:

  • Adult:  25-50mg, q8-12h (not to exceed 200mg per day)

Pain:

  • Adult: 75-150mg daily in three to four divided doses until pain alleviated

Gout:

  • Adult: 50mg tid until attack subsides

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

 
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