Morphine (MS Contin, Duramorph)

Category:

  • Analgesic

Description:

  • Opiate agonist analgesic

Indications:

  • Severe, acute pain

  • Moderate to severe chronic pain

  • Anesthesia adjunct for preoperative sedation

Contraindications:

  • Patients with impaired respiratory function.

Precautions:

  • Pregnancy Category C

  • In patients with myocardial infarction, morphine decreases systemic vascular resistance which may lead to severe hypotension.  To minimize, administer minimum effective dose and elevate patientís legs.

  • Rapid administration may induce respiratory depression, therefore monitor patientís respiratory function.

  • Patients will experience CNS effects of drowsiness and dizziness, therefore use caution with motor vehicle operation or other hazardous tasks.

  • Avoid prolonged, sustained usage to decrease addiction potential.

  • Use with caution with other CNS depressive medications.

Adverse Reactions (Side Effects):

  • Sedation

  • Dizziness

  • GI effects (nausea, vomiting, constipation)

Dosage:

Administered in smallest effective dose, as infrequently as possible and titrated to pain control

Administered orally, rectally, SQ, IM, slow IV, slow IV infusion, epidural and intrathecal (IT) injection

Adult:

  • Normal oral: 10-30mg 14h as needed

  • Normal rectal: 10-20mg q4h as needed

  • Normal SQ or IM: 10mg (range 5-20mg) q4h as needed

  • Normal IV: 2.5-15mg diluted in 4-5 mL sterile water for injection, slowly injected over 4-5 minutes

Labor anesthesia:

  • 10mg SQ or IM

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

 
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