Morphine (MS Contin, Duramorph)


  • Analgesic


  • Opiate agonist analgesic


  • Severe, acute pain

  • Moderate to severe chronic pain

  • Anesthesia adjunct for preoperative sedation


  • Patients with impaired respiratory function.


  • Pregnancy Category C

  • In patients with myocardial infarction, morphine decreases systemic vascular resistance which may lead to severe hypotension.  To minimize, administer minimum effective dose and elevate patientís legs.

  • Rapid administration may induce respiratory depression, therefore monitor patientís respiratory function.

  • Patients will experience CNS effects of drowsiness and dizziness, therefore use caution with motor vehicle operation or other hazardous tasks.

  • Avoid prolonged, sustained usage to decrease addiction potential.

  • Use with caution with other CNS depressive medications.

Adverse Reactions (Side Effects):

  • Sedation

  • Dizziness

  • GI effects (nausea, vomiting, constipation)


Administered in smallest effective dose, as infrequently as possible and titrated to pain control

Administered orally, rectally, SQ, IM, slow IV, slow IV infusion, epidural and intrathecal (IT) injection


  • Normal oral: 10-30mg 14h as needed

  • Normal rectal: 10-20mg q4h as needed

  • Normal SQ or IM: 10mg (range 5-20mg) q4h as needed

  • Normal IV: 2.5-15mg diluted in 4-5 mL sterile water for injection, slowly injected over 4-5 minutes

Labor anesthesia:

  • 10mg SQ or IM

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

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