Naproxen (Anaprox, Naprosyn)

Category:

  • Analgesic

Description:

  • Nonsteroidal anti-inflammatory drug (NSAID) analgesic

Indications:

  • Inflammatory disease (rheumatoid and osteoarthritis)

  • Mild to moderate pain (orthopedic pain, dental procedures, dysmenorrhea)

  • Fever

  Contraindications:

  • Patients with aspirin or NSAID-induced nasal polyps, bronchospasm or angioedema

  Precautions:

  • Pregnancy Category B

  • Patients may experience potentially serious GI effects, including GI bleeding and ulceration with prolonged, high dose therapy.

  • Avoid use with anticoagulants (warfarin) due to increased bleeding times and potential for GI bleeding and decreased platelet aggregation.

  • Liver function tests should be performed periodically for long-term naproxen use.

  Adverse Reactions (Side Effects):

  • GI effects (nausea, heartburn, dyspepsia, pain)

  • CNS effects (dizziness, headache, nervousness)

  • Tinnitis

Dosage:

Administered orally with food or milk to decrease GI effects

Inflammatory diseases:

  • Adult:  250-500mg bid (275-550mg of naproxen sodium) or 750-1000mg extended release tablets once a day (825 or 1100mg of naproxen sodium)

Pain:

  • Initial dose of 500mg, followed by 250mg q6-8h as needed

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