Levonorgestrel and Ethinyl Estradiol (Nordette)


  • Hormonal


  • Monophasic oral contraceptive

  • Nordette: levonorgestrel 0.15mg, ethinyl estradiol 30mcg


  • Contraceptive


  • Pregnancy and lactation

  • Undiagnosed abnormal vaginal bleeding

  • Known or suspected benign or malignant liver tumors while on oral contraceptive use

  • Breast carcinoma or estrogen-dependent neoplasia
  • Current or history of thromboembolic disorders, cerebral vascular or cardiovascular disease.


  • Pregnancy category X

  • Take as directed at intervals not exceeding 24 hours.  Efficiency is dependent upon strict compliance.

  • Breakthrough bleeding (“spotting”) may occur during initiation of therapy.

  • Instructions for missed doses:

    • One missed dose: Take as soon as possible or two tablets the next day and continue

    • Two missed doses: Take two tablets daily for two days, then continue normal schedule

    • Three missed doses: Discontinue therapy and begin new packet 7 days following last dose

  • May cause mental depression, fluid retention and depressed folate levels

  • Twenty-eight day packs contain seven days of inert ingredients to maintain regimen

  • Begin therapy on the fifth day of the cycle.  Day one of cycle is the first day of menstrual bleeding.

Adverse Reactions (Side Effects):

  • Abdominal cramping, anorexia, nausea, vomiting

  • Acne

  • Edema, weight gain

  • Unusual tiredness or weakness

  • Cardiovascular disorders (hypertension)

  • Thromboembolic disorders


Administered orally

  • One tablet daily for 21 or 28 days beginning on the fifth day of the cycle

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C.

Operational Medicine 2001
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
 May 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida

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