Oxacillin (Bactocill)


  • Antibiotic


  • Penicillinase-Resistant Penicillin


  • Mild to moderate infections caused by penicillinase-producing staphylococci

  • Upper Respiratory Tract Infections

  • Localized soft tissue/skin infections

  • Lower Respiratory Tract Infections

  • Disseminated infections


  • None


  • Pregnancy category B

  • Use with caution in patients with penicillin or cephalosporin allergy (5-10% chance of cross-reactivity)

  • Counsel patient to finish all medication to prevent development of resistance

  • Inform patient to take at even intervals, preferably around the clock

  • Take on an empty stomach, 1 hour before or 2 hours after meals.  Food inhibits absorption

  • Parenteral dosage form should not be run in same IV line as other medications

  • Inject intravenous injection slowly over a period of 10 minutes

Adverse Reactions (Side Effects):

  • Hypersensitivity

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  


Administered orally (capsules and oral suspension) and injectable

  • Oral

    • Adult and children (>40kg):

      • 500mg q4-6h (may increase to 1 gram q4-6h for severe infections)

    • Infants and children (<40kg):

      • 50mg/kg/day in divided doses every 6 hours

    • Neonates (>2kg) (age < 7 days):

      • 75mg/kg/day divided every 8 hours

    • Neonates (>2kg) (age > 7 days):

      • 150mg/kg/day every 6 hours

    • Neonates (<2kg):

      • 50mg/kg/day divided every 12 hours

  • Injectable

    • Adult and children (>40kg):

      • 250-500mg IM or IV q4-6h (up to 1 gram q-46h for severe infections)

    • Infants and children (<40kg):

      • 50mg/kg/day IM or IV in equally divided doses every 6 hours

      • severe infections: 100mg/kg/day IM or IV in equally divided doses every 4-6 hours

    • Premature/Neonates:

      • 25mg/kg/day IM or IV in divided doses

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