Pseudoephedrine (Sudafed)


  • Sympathomimetic


  • Decongestant


  • Nasal decongestion associated with common cold, allergies, and sinusitis

  • Promotes nasal or sinus drainage


  • Hypersensitivity to sympathomimetics, severe hypertension

  • Severe coronary artery disease


  • Pregnancy category C; compatible with breast feeding

  • Heart diseased, coronary insufficiency, dysrhythmias, angina

  • Hyperthyroidism, diabetes, mellitus, prostatic hypertrophy

  • Increased intracranial pressure, hypovolemia, mild to moderate hypertension

Adverse Reactions (Side Effects):

  • CNS: anxiety, confusion, dizziness, drowsiness, hallucinations, headache, insomnia, tremors

  • CV: chest pain, dysrhythmias, palpitations, tachycardia

  • GI: anorexia, nausea, vomiting

  • GU: dysuria, urinary retention

  • METAB: hyperglycemia


Administered orally (tablet, syrup, sustained release tablet/capsule)

  • Adult:   PO 60mg every 4-6 hours; PO SUS REL 120mg every 12 hours or 240mg once daily, max 240mg daily

  • Child:   PO 6-11 years 30mg every 4-6 hours, max 120mg daily; 2-5 years 15mg every 4-6 hours, max 60mg daily; <2 years 4 mg/kg/day divided every 6 hours

Drug interactions:

  • MAOIs: hypertensive crisis

  • Antacids: sodium bicarbonate doses sufficient to alkalinize urine can inhibit elimination of pseudoephedrine


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